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2 edition of selectivity of human placenta in maternal-foetal transfer of plasma proteins found in the catalog.

selectivity of human placenta in maternal-foetal transfer of plasma proteins

J. Lubega

selectivity of human placenta in maternal-foetal transfer of plasma proteins

mechanisms and implications

by J. Lubega

  • 33 Want to read
  • 22 Currently reading

Published .
Written in English


Edition Notes

Thesis(Ph.D.) - Loughborough University of Technology 1984.

Statementby J. Lubega.
ID Numbers
Open LibraryOL20029097M

Cholesterol is indispensable for cellular membrane composition and function. It is also a precursor for the synthesis of steroid hormones, which promote, among others, the maturation of fetal organs. A role of the ATP-binding-cassette-transporter-A1 (ABCA1) in the transport of maternal cholesterol to the fetus was suggested by transferring cholesterol to apolipoprotein-A-1 (apo-A1), but the. Glucose uptake and transfer depend on maternal-fetal concentrationgradient uptake transfer Maternal - fetal LCPUFA are enriched in foetal plasma Innis S, Placenta 26 Suppl A:S70, Maternal plasma Foetal plasma n-6 n-6 n-3 The human placenta does not appear to limit maternal-to-foetal flux of glucose (and fatty acids).

The placenta, specifically the syncytiotrophoblast, is an important endocrine organ during much of pregnancy. It produces protein and steroid hormones. The first protein hormone produced is human chorionic gonadotropin (HCG), which is responsible for maintaining the corpus luteum and its production of progesterone and estrogens. With HCG. The placenta promotes fetal growth through nutrient transfer and selective barrier systems. An optimally developed placenta can adapt to changes in the pregnancy environment, buffering the fetus.

  The degree and selectivity of protein binding by corticosteroids affect its biological activity. Only the non‐protein‐bound fraction is biologically active. Plasma binding of synthetic betamethasone and dexamethasone is 60% and 75%, respectively, which is constant across a wide concentration range. Maternal–fetal exchange via the transcellular route involves transfer across the two polarized plasma membranes of the syncytiotrophoblast. The transfer of a molecule across the placental barrier can be limited by the rate of blood flow on the two sides of the barrier (“flow-limited” transport) and/or by diffusion across the barrier.


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Selectivity of human placenta in maternal-foetal transfer of plasma proteins by J. Lubega Download PDF EPUB FB2

The selectivity of human placenta in maternal-foetal transfer of plasma proteins: mechanisms and implications This item was submitted to Loughborough University's Institutional Repository by the/an author.

Additional Information: • A Doctoral Thesis. Submitted in partial ful lment of the requirements for. j clin invest. oct; the selectivity of the human placenta in the transfer of plasma proteins from mother to fetus.

gitlin d, kumate j, urrusti j, morales by: The Selectivity of the Human Placenta in the Transfer of Plasma Proteins from Mother to Fetus * David Gitlin, Jesús Kumate, Juan Urrusti, and Carlos Morales Hospital Infantil de México, the Hospital de Gineco-Obstetricia, Centro Médico Nacional del I.M.S.S., México, D.

by: The Selectivity of the Human Placenta in the Transfer of Plasma Proteins from Mother to Fetus. In this study the selectivity of the transfer of 7 S y2-globulin was reinvestigated in the pregnant woman by using several labeled human proteins of different molecular weights and fragments of 7 Sy2-globulin obtained bypapainhydrolysis.

Methods Plan of study. Normal women in their last month of an uncomplicated pregnancy were given mgof. The selectivity of human placenta in maternal-foetal transfer of plasma proteins: mechanisms and implications Author: Lubega, John ISNI: Awarding Body: Loughborough University of Technology Current Institution: Loughborough University Date of Award.

Placental lactogen or chorionic somatomammotropin (CSH) was initially purified from the human placenta close to 60 years ago. CSH production begins during the early stages of placental development, continues throughout gestation, is one of the most abundantly produced placental proteins, and is secreted into both the maternal and fetal circulation.

The transfer of ICG to cord blood has been shown in humans to be very low,, attributed to high binding to plasma proteins, and limited diffusion.

Our findings, using the dually-perfused human placenta, agree with a very low fetal:maternal ICG ratio. GITLIN D, KUMATE J, URRUSTI J, MORALES C. THE SELECTIVITY OF THE HUMAN PLACENTA IN THE TRANSFER OF PLASMA PROTEINS FROM MOTHER TO FETUS.

J Clin Invest. Oct; – [PMC free article] Hay FC, Hull MG, Torrigiani G. The transfer of human IgG subclasses from mother to foetus.

Clin Exp Immunol. Sep; 9 (3)–   Since β-carotene travels in the maternal bloodstream in association with lipoproteins, it was expected that key players of the lipoprotein metabolic pathway would be implicated in its maternal-fetal transfer. In human term placenta LDLR and LDLR-related protein 1 (LRP1) have been localized in the syncytiotrophoblast facing the maternal blood.

The selectivity of human placenta in maternal-foetal transfer of plasma proteins: mechanisms and implications. By John Lubega. Abstract. A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy of Loughborough University.

The major plasma proteins detected were alphaantitrypsin, alpha-fetoprotein, transthyretin,β-2 microglobulin, and plasminogen, with lower levels of transferrin and complement C4 released. PROBLEM: The transport of various proteins across the human placenta was investigated by comparing maternal and fetal concentrations of tetanus antigen (TT‐AG), anti‐tetanus (TT)‐immunoglobulin G (IgG) (following maternal vaccination), IgA, human chorionic gonadotropin (hCG), human placental lactogen (hPL), and alpha‐fetoprotein (AFP) at term.

The Selectivity of the Human Placenta in Maternal Foetal Transfer of Plasma Proteins; Mechanisms and Implications. Ph.D. Thesis, University of Loughborough, UK, Chemical Cross-Linking of HFE Protein-β 2 M-Transferrin Receptor Complex. The membrane suspension of a human term placenta specimen was mixed with a reversible bifunctional cross-linker, 1 mM dithiobis (succinimidyl propionate) in 50 mM sodium phosphate buffer, pHcontaining the protease inhibitors, and the mixture was incubated at room temperature for 10 min ().

Uptake of long chain fatty acids by human placental choriocarcinoma (BeWo) cells: role of plasma membrane fatty acid-binding protein. Lipid Res. 38, – ; Campbell F. M., Dutta-Roy A. Plasma membrane fatty acid-binding protein (FABPpm) is exclusively located in the maternal facing membranes of the human placenta.

This process, similar to the situation in the yolk sac, is facilitated by MTTP. Recently, Scholler et al. reported a novel step in the maternal-fetal cholesterol transport mechanism by phospholipid transfer protein (PLTP).

PLPT is expressed in the placental endothelium where it acts as a mediator in the formation of HDL particles. The placenta is the organ through which gases, nutrients, and wastes are exchanged between the maternal-fetal circulations.

The size, morphology, and nutrient transfer capacity of the placenta determine the prenatal growth trajectory of the fetus to influence birth weight.

Because the plasma concentration of each amino acid is generally higher in the fetal circulation than in the maternal circulation, amino acids are thought to be actively transported across the maternal–fetal barrier.

In fact, the human placenta expresses over 20 amino acid transporters. The placenta is a temporary organ that connects the developing fetus via the umbilical cord to the uterine wall to allow nutrient uptake, thermo-regulation, waste elimination, and gas exchange via the mother's blood supply; to fight against internal infection; and to produce hormones which support pregnancy.

Placentas are a defining characteristic of placental mammals, but are also found in. Glazier JD, Cetin I, Perugino G, Ronzoni S, Grey AM, Mahendran D, et al., Association between the activity of the system A amino acid transporter in the microvillous plasma membrane of the human placenta and severity of fetal compromise in intrauterine .16 ABC Transporters in Human Placenta and Their Role in Maternal-Fetal Cholesterol Transfer: ABCA1 Candidate Target Jayonta Bhattacharjee1,2, Francesca Ietta1.

Optimal development of the embryo and the fetus depends on placental passage of gases, nutrients, hormones, and waste products. These molecules are transferred across the placenta via passive diffusion, carrier-mediated cellular uptake and efflux, and transcytosis pathways.

The same mechanisms additionally control the rate and extent of transplacental transfer of drugs taken by the .